منابع مشابه
HIV latency.
HIV-1 can establish a state of latent infection at the level of individual T cells. Latently infected cells are rare in vivo and appear to arise when activated CD4(+) T cells, the major targets cells for HIV-1, become infected and survive long enough to revert back to a resting memory state, which is nonpermissive for viral gene expression. Because latent virus resides in memory T cells, it per...
متن کاملBioinformatics and HIV Latency
Despite effective treatment, HIV is not completely eliminated from the infected organism because of the existence of viral reservoirs. A major reservoir consists of infected resting CD4+ T cells, mostly of memory type, that persist over time due to the stable proviral insertion and a long cellular lifespan. Resting cells do not produce viral particles and are protected from viral-induced cytoto...
متن کاملViral latency in HIV disease
The term "latency" is often applied to infections caused by herpesviruses, wherein viral replication and disease manifestations appear concordantly after long intervals of silence. In the case of the human immunodeficiency virus (HIV), an asymptomatic period of "clinical latency" can intervene between infection and the development of the acquired immune deficiency syndrome (AIDS). Freedom from ...
متن کاملA Hardwired HIV Latency Program
Biological circuits can be controlled by two general schemes: environmental sensing or autonomous programs. For viruses such as HIV, the prevailing hypothesis is that latent infection is controlled by cellular state (i.e., environment), with latency simply an epiphenomenon of infected cells transitioning from an activated to resting state. However, we find that HIV expression persists despite t...
متن کاملMolecular mechanisms of HIV latency
Historical perspective AIDS first came to public attention in 1981 (1) and represented an acquired immunodeficiency, which invariably led to the demise of the infected individual. Thus, whatever the transmissible agent, the immune system could not eliminate the infection. HIV, which proved to be a retrovirus of the lentivirus family, was identified as the causative agent two years later (2). Th...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Medicine
سال: 2011
ISSN: 2157-1422
DOI: 10.1101/cshperspect.a007096